Milk thistle is an ancient plant with a pinkish purple flower that was used historically as medicine. Today, it’s a popular supplement for supporting liver health. The high levels of antioxidants, including the flavonoid silymarin responsible for many of milk thistle’s disease-preventing benefits. You can take milk thistle as a capsule or herbal extract, though you can also brew milk thistle tea. Here are five health benefits of milk thistle proven by research:

1. Supports Liver Health

As detoxifier of your blood, the liver is constantly processing toxins. These toxins can damage the liver if it’s not protected by antioxidants. Antioxidants neutralize free radicals, which are damage-causing molecules from toxins. Some antioxidants, such as glutathione, are produced naturally by your liver, though this production declines with age. In addition to supplying antioxidants itself, milk thistle has also been found to boost the liver’s own production of glutathione.


The most powerful active substance in milk thistle is silymarin — an antioxidant shown to protect liver cells against mutation and damage. It acts as a toxin blockade by preventing toxins from binding to receptors on liver cell membranes.^[1] These findings suggest milk thistle could be a useful agent in helping to prevent liver cirrhosis, liver disease, and potentially liver cancer.

2. Protects the Aging Brain

Amyloid plaque buildup in the brain is the major cause behind the progression of dementia and <span class=”glossaryLink” aria-describedby=”tt” data-cmtooltip=”

Alzheimer’s

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>Alzheimer’s disease. As the brain ages, the natural detoxification mechanisms can fail to remove all the amyloid plaque buildup during sleep. Milk thistle may be able to help by reducing amyloid plaque in the brain, as it’s been shown to do in animal studies.^[2]

While there are no human studies on milk thistle’s effects on people with neurodegenerative diseases, the anti-inflammatory and antioxidant properties of milk thistle could assist in mitigating the effects of aging on the brain.

Traditional milk thistle extract is made from the seeds.

3. Supports Healthy Blood Sugar Levels

The active substance in milk thistle known as silymarin can also help control blood sugar levels. A review published in the Journal of Diabetes Research looked at five clinical trials involving 270 patients. It concluded that silymarin significantly reduces blood sugar levels and could potentially help diabetics and prediabetics with glycemic control.^[3] Drinking milk thistle tea with a meal may help prevent blood sugar spikes, and supplementing with milk thistle regularly could lower your risk of developing diabetes.

4. May Help Fight Cancer

The silymarin in milk thistle may help in preventing the development of cancer. It works by supporting the body’s natural immune response against cancer cells and by directly inhibiting tumor growth. In test tube studies, silymarin has been shown to protect against breast, prostate, bladder, skin, colon, kidney, and lung cancers.^[4] Human trials are lacking, but antioxidants like silymarin found in milk thistle show promise in research done outside the body.

5. Increases Breast Milk Production

Silymarin in milk thistle is a galactagogue, which means it increases the production and flow of breast milk in lactating mothers. In a 2-month study, mothers taking 420 mg of silymarin daily increased their breast milk production by 86% compared to mothers taking a placebo. The study also confirmed silymarin supplementation did not affect the quality of the milk supply, which means it’s a great remedy for lactating mothers struggling with low milk supply.^[5]

6. Improves Acne

Acne treatments are typically topical products applied to the face. Interestingly, oral supplementation with milk thistle has been linked to improved acne symptoms. In one study on 56 patients, just eight weeks of milk thistle intervention reduced acne lesion count by 53%. The researchers attributed these results to the antioxidant and anti-inflammatory properties of milk thistle.^[6]

7. Supports Bone Health in Postmenopausal Women

Supplementing consistently with milk thistle could help menopausal and postmenopausal women prevent osteoporosis — the thinning of bone density that puts your bones at high risk of fracturing and breaking. Postmenopausal women are at the highest risk of osteoporosis because the loss of estrogen is linked to a loss of bone density.

The silymarin in milk thistle makes it a phytoestrogen, which means it acts on estrogen receptors and has estrogen-like effects when estrogen levels are deficient. In a mouse model of osteoporosis caused by estrogen deficiency, oral administration of milk thistle was found to reduce bone loss.^[7]

Milk Thistle for Liver Health and Beyond

While milk thistle is best known for its liver health benefits, it’s also a natural remedy that can help with acne, low breast milk supply, high blood sugar, and potentially even age-related cognitive decline. Milk thistle also helps prevent cancer, osteoporosis in women, and illnesses of the liver. Some milk thistle supplements are concentrated in silymarin, while other capsules contain the whole powder ground. As with any herb, it’s important to stay within the recommended daily dose written on the product label.


References:

1. “Milk thistle in liver diseases: past, present, future” by Ludovico Abenavoli, Raffaele Capasso, Natasa Milic and Francesco Capasso, 7 June 2010, Phytotherapy Research.
   DOI: 10.1002/ptr.3207
2. “Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model” by Nakaba Murata, Kazuma Murakami, Yusuke Ozawa, Noriaki Kinoshita, Kazuhiro Irie, Takuji Shirasawa and Takahiko Shimizu, 23 November 2010, Bioscience, Biotechnology, and Biochemistry.
   DOI: 10.1271/bbb.100524
3. “Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” by Luminita Voroneanu, Ionut Nistor, Raluca Dumea, Mugurel Apetrii and Adrian Covic, 1 June 2016, Journal of Diabetes Research.
   DOI: 10.1155/2016/5147468
4. “Silibinin – A Promising New Treatment for Cancer” by Catherine Wing Ying Cheung, Norma Gibbons, David Wayne Johnson and David Lawrence, 2010, Anti-Cancer Agents in Medicinal Chemistry.
   DOI: 10.2174/1871520611009030186
5. “Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue” by Francesco Di Pierro, Alberto Callegari, Domenico Carotenuto and Marco Mollo Tapia, December 2008, Acta Biomedica Atenei Parmensis.
   PMID: 19260380
6. “Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne” by Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Mohammed Salih and Fatima Abdullah, 2012, Journal of Clinical & Experimental Dermatology Research.
   DOI: 10.4172/2155-9554.1000163
7. “Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis” by Jung-Lye Kim, Yun-Ho Kim, Min-Kyung Kang, Ju-Hyun Gong, Seoung-Jun Han and Young-Hee Kang, 28 May 2013, BioMed Research International.
   DOI: 10.1155/2013/919374

A recent study of mice conducted by researchers at The University of Texas at Dallas found that short-term consumption of a high-fat diet may be linked to pain sensations, even without a preexisting injury or condition such as obesity or diabetes.

The study, published in <span class=”glossaryLink” aria-describedby=”tt” data-cmtooltip=”

Scientific Reports

Established in 2011, <em>Scientific Report</em>s is a peer-reviewed open-access scientific mega journal published by Nature Portfolio, covering all areas of the natural sciences. In September 2016, it became the largest journal in the world by number of articles, overtaking <em>PLOS ON</em>E.

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>Scientific Reports, compared the effects of different diets on two groups of mice. One group was fed normal chow, while the other was given a high-fat diet that did not cause obesity or high blood sugar, both of which can lead to diabetic neuropathy and other types of pain.


The researchers found that the high-fat diet induced hyperalgesic priming — a neurological change that represents the transition from acute to chronic pain — and allodynia, which is pain resulting from stimuli that do not normally provoke pain.

“This study indicates you don’t need obesity to trigger pain; you don’t need diabetes; you don’t need a pathology or injury at all,” said Dr. Michael Burton, assistant professor of neuroscience in the School of Behavioral and Brain Sciences and corresponding author of the article. “Eating a high-fat diet for a short period of time is enough — a diet similar to what almost all of us in the U.S. eat at some point.”

Dr. Michael Burton (from left), Calvin D. Uong, and Melissa E. Lenert found that a type of fatty acid called palmitic acid binds to a particular receptor on nerve cells, a process that results in inflammation and mimics injury to the neurons. Credit: University of Texas at Dallas

The study also compared obese, diabetic mice with those that just experienced dietary changes.

“It became clear, surprisingly, that you don’t need an underlying pathology or obesity. You just needed the diet,” Burton said. “This is the first study to demonstrate the influential role of a short exposure to a high-fat diet to allodynia or chronic pain.”

Western diets are rich in fats — in particular, saturated fats, which have proved to be responsible for an epidemic of obesity, diabetes, and associated conditions. Individuals who consume high amounts of saturated fats — like butter, cheese, and red meat — have high amounts of free fatty acids circulating in their bloodstream that in turn induce systemic inflammation.

Recently, scientists have shown that these high-fat diets also increase existing mechanical pain sensitivity in the absence of obesity and that they can aggravate preexisting conditions or hinder recovery from injury. No studies, however, have clarified how high-fat diets alone can be a sensitizing factor in inducing pain from nonpainful stimuli, such as a light touch on the skin, Burton said.


“We’ve seen in the past that, in models of diabetes or obesity, only a subsection of the people or animals experience allodynia, and if they do, it varies across a spectrum, and it isn’t clear why,” Burton said. “We hypothesized that there had to be other precipitating factors.”

Burton and his team looked for saturated fatty acids in the blood of the mice fed the high-fat diet. They found that a type of fatty <span class=”glossaryLink” aria-describedby=”tt” data-cmtooltip=”

acid

Any substance that when dissolved in water, gives a pH less than 7.0, or donates a hydrogen ion.

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]”>acid called palmitic acid — the most common saturated fatty acid in animals — binds to a particular receptor on nerve cells, a process that results in inflammation and mimics injury to the neurons.

“The metabolites from the diet are causing inflammation before we see pathology develop,” Burton said. “Diet itself caused markers of neuronal injury.

“Now that we see that it’s the sensory neurons that are affected, how is it happening? We discovered that if you take away the receptor that the palmitic acid binds to, you don’t see that sensitizing effect on those neurons. That suggests there’s a way to block it pharmacologically.”



Burton said the next step will be to focus on the neurons themselves — how they are activated and how injuries to them can be reversed. It is part of a larger effort to understand better the transition from acute to chronic pain.

“The mechanism behind this transition is important because it is the presence of chronic pain — from whatever source — that is fueling the opioid epidemic,” he said. “If we figure out a way to prevent that transition from acute to chronic, it could do a lot of good.”

Burton said he hopes his research encourages healthcare professionals to consider the role diet plays in influencing pain.

“The biggest reason we do research like this is because we want to understand our physiology completely,” he said. “Now, when a patient goes to a clinician, they treat a symptom, based on an underlying disease or condition. Maybe we need to pay more attention to how the patient got there: Does the patient have diabetes-induced or obesity-induced inflammation; has a terrible diet sensitized them to pain more than they realized? That would be a paradigm shift.”



Reference: “High-fat diet causes mechanical allodynia in the absence of injury or diabetic pathology” by Jessica A. Tierney, Calvin D. Uong, Melissa E. Lenert, Marisa Williams and Michael D. Burton, 1 September 2022, Scientific Reports.
DOI: 10.1038/s41598-022-18281-x

The study was funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the UT System STARS (Science and Technology Acquisition and Retention) program, the American Pain Society, and the Rita Allen Foundation.