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Barcelona Opera has hired a coordinator for intimate scenes

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Intimate Scene Co-ordinator Ita O’Brien will direct the adaptation of William Shakespeare’s Antony and Cleopatra, which will be performed on the Gran Teatre del Liceu stage from 28 October

The Barcelona Opera House has hired an “intimacy coordinator” to ensure performers feel comfortable when taking part in passionate scenes, Reuters reported, cited by BTA.

This is happening for the first time in Spain and is rare for continental Europe.

The creation of such a position came after the #METOO movement rocked not only the film industry, but also the world of opera with allegations of sexual harassment.

Intimate Scene Co-ordinator Ita O’Brien will direct the adaptation of William Shakespeare’s Antony and Cleopatra, which will be performed on the Liceu Grand Theater stage from 28 October.

O’Brien, who has consulted on intimacy issues for HBO and Netflix productions, says operas have always revolved around dramatic stories and that historically, performers arrived in town just days before the premiere and were not expected to discuss intimate scenes.

“Without that process of consent and seeking consent, people have been left feeling awkward, harassed, absolutely abused,” says Ita O’Brien.

The specialist, who has 40 years of experience in musical theater and acting, is the founder of the organization Intimacy On Set, which provides support in the television and film industries.

During rehearsals, O’Brien invites performers to “connect with a hug,” then discuss where they feel comfortable being touched and what makes them uncomfortable.

“We’re inviting the contractor to really tell us where their boundaries are, and that’s a big shift in the industry,” she says. “Your yes is yes, your no is no, and maybe is no,” adds the expert.

Mezzo-soprano Adriana Bignani Lesca, who plays Cleopatra’s handmaiden and has a kiss scene with another woman, thinks the opera should have a coordinator of intimate scenes.

In the United States and Great Britain, such experts have previously been used in the creation of television shows and operas.

In January, famous Spanish opera singer Plácido Domingo was again accused of sexual harassment – three years after similar allegations forced him to apologize and marred his career. Domingo denies any wrongdoing.

Photo by Aleksandar Pasaric: https://www.pexels.com/photo/aerial-photography-of-high-rise-buildings-1386444/

Large snails can be dangerous as pets

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About two-thirds of at least 36 known snail pathogens can also infect humans.

Large African snails up to 20 centimeters in length are experiencing a boom as pets in Europe, but Swiss scientists warn against breeding them, DPA reported.

Animals can be dangerous to humans, for example by carrying lung parasites from rats. This can cause meningitis in humans, reports a team of scientists from the University of Lausanne in a publication in the scientific journal Parasites & Vectors.

About two-thirds of at least 36 known snail pathogens can also infect humans. Among the popular species for terrariums are the large African snails of the species Lissachatina fulica and Achatina achatina.

“Social media is full of pictures of people putting the animal in contact with their skin or even their mouth,” said researcher Cleo Bertelsmeier, quoted in a university statement.

She teaches at the Institute of Ecology and Evolution at the Faculty of Biology and Medicine. People believe that snail slime is good for the skin. However, this carries the risk of transmitting pathogens.

Bertelsmeier and her colleagues analyzed photos on social media to see how widespread large snails are as pets.

Many people are not aware of the risks “they are exposing themselves or their children to when they handle snails, for example when they put them on their face,” says co-author Jerome Gippe.

The researchers warn that if the pet trade grows, “it will create more opportunities for the introduction and spread of harmful pathogens to humans and other animals.”

African snails are gluttonous and reproduce quickly. The International Union for Conservation of Nature has included them in its list of dangerous invasive species and defines them as pests, reminds DPA.

Helping Neighbors Near and Far

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The Scientology Volunteer Ministers (VMs) recently organized a cleanup operation in Rome and another of their teams provided flood relief in Florence.

ROME, ROME, ITALY, November 15, 2023 /EINPresswire.com/ — Scientologists in Italy often participate in helping their communities during local disasters, by joining their Volunteer Ministers program.

The Scientology Volunteer Ministers Program was launched over 30 years ago by L. Ron Hubbard, founder of Scientology, as a way to help people suffering from disasters and injustice. As Hubbard said, “If one does not like the crime, cruelty, injustice and violence of this society, he can do something about it.”(1)

The yellow-shirted VMs recently gathered at the Via Boccea junction near Rome’s Grande Raccordo Anulare ring road to clean up and enhance the landscape. The Roman group collected 6 bags of garbage and 150 glass bottles, discovering waste paper, cans, plastic, and dry leaves along the roadsides. Another team of VMs in Rome also organized a cleanup along the Via Boccea to improve their city. They collected trash and cleared landscaping debris from the roadsides near the highway.

In early November, severe storms led to major flooding in Florence and its surrounding areas. VMs were dispatched to assist with debris clearance in the province of Florence. In Campi Bisenzio, a municipality near Florence, the VMs worked to remove obstructions, enabling other rescue vehicles to reach the flooded areas. Coordinated by the Campi Bisenzio Town Council, the VMs made three trips to dispose of over 30 cubic meters of rubble collected from flooded homes and streets in Campi Bisenzio. Local residents of Florence showed their gratitude by offering discounted accommodations and complimentary breakfast to the VMs.

The VMs plan to continue relief efforts in Tuscany in the coming days, while also conducting local community service projects in other Italian cities. As Hubbard wrote, “A Volunteer Minister does not shut his eyes to the pain, evil and injustice of existence. Rather, he is trained to handle these things and help others achieve relief from them and new personal strength as well. How does a Volunteer Minister accomplish these miracles? Basically, he uses the technology of Scientology to change conditions for the better—for himself, his family, his groups, friends, associates and for mankind.” (4)

“Italian Scientologists are always very eager to help civilize society by promoting awareness, kindness, freedom from suffering, trust, decency, honesty and tolerance,” said Scientology representative to the EU Ivan Arjona. “Their initiatives will continue in the coming weekends around Italy”.

References:
(1) https://www.scientology-losangeles.org/news/humanitarian-activities/scientology-volunteer-ministers-help-the-local-community-with-a-food-drive-0d5f4e
(2) https://www.romatoday.it/zone/aurelio/boccea/interventi-di-cura-per-l-ambiente-nella-capitale.html
(3) https://www.firenzetoday.it/cronaca/rifiuti-campi-bisenzio.html
(4) https://www.volunteerministers.org/newsletter/2016-06-40-years-scientology-volunteer-minister-help.html

At UK’s AI Summit, Guterres says risks outweigh rewards without global oversight

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At UK’s AI Summit, Guterres says risks outweigh rewards without global oversight

Addressing the Summit on Artificial Intelligence Safety convened by the United Kingdom, at the famous Bletchley Park estate – where Allied code breakers made a huge contribution to the war effort cracking Nazi codes – the UN chief emphasized the need for “sustained and structured conversation” around its risks, challenges and opportunities.

“The United Nations – an inclusive, equitable and universal platform for coordination on AI governance – is now fully engaged in that conversation,” he said.

Three key areas

The Secretary-General outlined three key areas for immediate action.

First, he called for addressing existing threats related to the release of powerful AI models which currently lack sufficient guardrails and oversight.

Second, Mr. Guterres expressed concerns about the long-term negative consequences of AI, including its impact on jobs; the erosion of cultural diversity erosion due to biased algorithms and the stoking of geopolitical tensions arising from the concentration of AI corporations in just a handful of countries.

The third concern was that in the absence of immediate action, AI will exacerbate inequalities that are already growing wider.

“This is not a risk; it’s a reality,” he warned.

Ethical principles

To address these concerns, Mr. Guterres mentioned the development of over 100 different sets of often overlapping ethical principles for AI.

While there is broad agreement on principles such as reliability, transparency, accountability and the ability to shut down AI applications, global oversight is needed to prevent incoherence and gaps, he urged.

The UN chief highlighted the launch of his new Advisory Body on AI, which consists of experts from government, business, the tech community, civil society, and academia.

“It is truly universal, with representation from all parts of the world, in order to foster the networked, inclusive, evidence-based solutions that are needed,” he said.

Partnerships for future

The Advisory Body will work in tandem with other global initiatives set up through the EU and the G7, for example, and will provide preliminary recommendations by the end of the year on building scientific consensus and making AI work for all of humanity.

These recommendations will feed in to the Global Digital Compact, proposed for adoption at the UN’s Summit of the Future next September.

“In other words — its work will embed AI governance into intergovernmental processes, and an established global Summit,” Mr. Guterres said.

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Russians not collectively to blame for Ukraine war: Human rights expert

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Russians not collectively to blame for Ukraine war: Human rights expert

In a recent interview conducted with UN News, she emphasised the significance of her report and its purpose, holding to account one of the five permanent members of the UN Security Council.

“It is unique that for the first time” one of the ‘P5’ permanent members of the Security Council has been subject to monitoring by another major UN body, the Human Rights Council, having just created the mandate of the Special Rapporteur on the situation of human rights the previous year, she said.

Civil society ‘completely destroyed’

The report describes in detail how the human rights situation in Russia began to deteriorate 20 years ago. It highlighted Russia’s persecution of anti-war demonstrators, torture of detained activists and opposition figures, and the targeting of lawyers who defend these groups. 

Russian journalist and prominent opposition activist Vladimir Kara-Murza, who is imprisoned in the Russian Federation.

The human rights situation has “gradually deteriorated” over the past 20 years, from the two Chechen wars, and then, after the full-scale armed attack on Ukraine in February last year, the human rights situation has “deteriorated dramatically,” said Ms. Katzarova.

The main “tragic finding is that civic space in the Russian Federation has been destroyed completely” she told UN News.

Refusal to cooperate

Ms. Katzarova’s access to the country has been restricted by the Russian Government, although this has not stopped her from collecting information from almost 200 sources both inside and outside Russia, including human rights activists, political activists, opposition voices and journalists.

Ms. Katzarova expressed hope that Russian authorities will allow her to visit the country soon. She also expressed a desire to communicate not only with representatives of civil society, but also with Government officials and officials working in the justice system.

She said she hoped the Russian authorities will change their minds and begin to communicate “with my mandate”, because “I’ve been appointed to help the authorities, as any other special rapporteur of the United Nations, we are there to assist”.

She said she had also contacted the Commissioner for Human Rights, Ms. Moskalkova as her role exists separately from the Government.

She was keen to have her input for her report as the human rights ombudsman, since the Russian people can turn to her with their complaints. “Unfortunately, she did not answer”, said the UN independent expert. 

Russians abroad

According to the expert, part of her job is to serve the Russian people, to give them the opportunity to be heard, amidst the current climate of general isolation. 

She recalled that many Russians left the country to avoid mobilisation or persecution for ideological and political reasons. The governments of the countries in which these Russians settled should provide them with support, she emphasised. 

As Russians now find it difficult to travel abroad, she said she had told representatives of other States, the European Union and Western governments to review the bans, as it “only isolates the people and serves the propaganda of the government…saying to the Russian people, well, the collective West does not like you because you’re Russian citizens.”

Fear of speaking out

The expert also emphasised that, given the numerous cases of persecution of media workers, human rights activists and lawyers, an atmosphere of fear has formed in the country.

Citizens are now afraid to express their opinions, in particular regarding the war. 

“I don’t believe that all Russian people are supporting any war, and particularly this war on Ukraine. Mind you, a lot of Russians actually relate to a lot of Ukrainians. I mean, there are mixed marriages”, Ms. Katzarova recalled. 

Special rapporteurs 

UN Special Rapporteurs are independent experts appointed by the UN Human Rights Council to review situations in individual countries or global thematic issues. They are not employees of the UN, do not represent any other organisation or government, work in a personal capacity and do not receive a salary from the UN for their work.

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US ‘at a critical juncture’ in fight against racism: Independent expert

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US ‘at a critical juncture’ in fight against racism: Independent expert

She travelled across the US between 31 October and 14 November, from Detroit in Michigan to the Louisiana coast, also visiting Los Angeles, Atlanta and Washington DC.

Ashwini K.P., UN Special Rapporteur on contemporary forms of racism, xenophobia and related intolerance, said following her 14-day fact finding mission that mainstream America was now more aware of systemic racism following the large scale racial protests of 2020 and the positive response from the Biden-Harris administration “to improve racial equality”.

But she also expressed shock at the “mutually reinforcing manifestations of systemic racism” she witnessed.

“These manifestations of racism impacted those from racially marginalised groups at every stage of their lives, historically, systematically and institutionally”, she said in her initial statement

UN News sat down for an interview with the independent expert after she presented her initial findings at a press conference in New York on Tuesday, telling us “selective amnesia” was an issue in some states when it comes to reckoning with race.

Special Rapporteurs and other Human Rights Council-appointed independent experts are not UN staff, nor do they receive payment for their work. They are independent from any government or organization.

The interview has been edited for clarity and length.

UN News: What was the purpose of your recent fact-finding mission in the US?

Just to give a background, independent experts and working groups on different issues, are assigned to conduct country missions, which are one of our official responsibilities. The US country mission happens to be my first official country mission, and the purpose is majorly to assess the country situation and my mandate covers racism, racial discrimination, xenophobia, and related intolerance.

And therefore, this is an intense exercise in terms of assessing the situation of racism, racial discrimination, and xenophobia in the country, and to critically analyse existing policies and legislation.

And the mission involves an intense interaction with state authorities, as well as Civil Society Organisations, academicians and many others who are working on racism and racial discrimination. I have just completed the country mission and it is too early for me to respond on the conclusion.

But I must say that racism very much persists and has manifested in different forms, and I’ll surely elaborate much more in the report that will be presented next year at the Human Rights Council. 

UN News: Has any of what you’ve seen surprised you?

Ashwini K.P: Coming from Global South, from India, the United States is very similar in terms of culture and diversity geographically, demographically as well. 

And as someone who has been an activist and being in the space, what surprises me is the resilience that activists here in the US have, the mobilization in terms of raising the issue and how they have reached the global platform and also in terms of research analysis – that advocacy and lobbying. 

In this I’m referring to the Black community, the Latino community, Brown and Black people, all the marginalized communities have organized amazingly. 

And that surprises me and inspires me.

Disheartened, not surprised

And, in terms of the realities of racism that I witnessed, and the lived experiences of survivors that I heard, rather than surprised, that disheartened me, disappointed me in terms of looking at how systemic racism can impact lives of individuals.

But of course, activism and academia, how they’ve addressed racism in the US has been amazing. And this can be an inspirational space for many oppressed communities across the globe to learn and take this forward.

UN News: Often the US is viewed as being very polarized across many different levels. Do you see that in terms of human rights?

Ashwini K.P: In terms of human rights, I think there are different narratives when it comes to different geographical locations and there is a certain level of selective amnesia, I would say, in terms of human rights that something is more important than the other.

There is this persisting selectiveness when it comes to addressing human rights, that this oppression is more important than the other.

I think that’s where the polarization lies in the very narrative of how human rights is placed, or even advocacy in global platforms. So, I see that very much in the United States and many other parts of the world as well.

But this has kind of created a rift in terms of how human rights can be addressed in a more effective manner, both in domestic and international platforms.

UN News: A lot of people in the Global North have a very Western perspective when it comes to human rights challenges…Do you think that’s a fundamental problem in how people perceive this conversation?

Ashwini K.P: I think it’s very important for many of us to take cognizance of the cultural differences that exist in various geographical locations. And human rights cannot be seen in isolation. That’s extremely important. And the narrative of human rights differs from state to state.

And there are several positive aspects of Western ideas of human rights. Likewise, I think it’s also important to take cognizance of the Global South human rights perspective.

The Global South human rights perspective is much more challenging, much more vibrant, and has several pertinent issues that can be put on the table to discuss. And that is always the space of collaboration when it comes to Global North and Global South and the gap that exist within the human rights narrative between Global South and Global North is something that has caused a lot of tension in terms of addressing human rights.

I think that is something that needs to be discussed. So, we need to build upon these narratives taking into account the political, social, and cultural differences that exist both in the Global South and Global North.

UN News: How do you think social media activism can support racism-related conversations? 

Ashwini K.P: Lovely question. And social media is something that is at its peak, and especially with technological advancement.

This has created a lot of space for marginalized communities, oppressed communities, majorly, historically oppressed communities, to express their view, to put their perspectives.

It has provided an immense space for activists and academicians to reach out to people. But at the same time, we have pros and cons of social media and that needs to be taken into consideration.

‘Receiving end’ of hate speech

While activists, youngsters from marginalized communities are quite active, but at the same time they are the ones at the receiving end when it comes to hate speech, when it comes to threat, life threat and many similar issues.

There is this strong connection between freedom of speech and hate speech, and that is something that needs to be recognized.

And I feel social media is something that needs to be protected. And these platforms need strong regulation in terms of what is disseminated. And one of the major worries is dissemination of misinformation and disinformation, which further escalates racism, racial discrimination, hate crimes, xenophobia.

It can be religious intolerance, and therefore, we have as activists, as propagators of human rights, we have to be mindful of what we put in before social media because it reaches out to millions of individuals.

And at the same time taking note of the positive impact that social media narratives can have. I think it is one of the best places where there can be a positive mobilization of activists and academicians and human rights propagators across the globe to make things better.

UN News: And are there any final thoughts you’d like to share? 

Ashwini K.P: My final thoughts would be in terms of the country mission, I think I’ve had one of the best experiences in the last 14 days inspiring, challenging, emotional, while I engaged with activists, Civil Society Organisations and many others.

It has been a wonderful experience. I think the moment and the space to take this challenge forward – to eliminate and eradicate racism or racial discrimination – should be taken very positively, in a mindful manner. 

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Moscow will block more virtual private networks that are a security risk

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Moscow will block more virtual private networks that are a security risk

Russia plans to block some virtual private networks (VPNs) it deems to pose a threat, Reuters reported, citing the Russian Ministry of Digital Development, Communications and Mass Communications.

Interest in VPN services has increased since Moscow banned access to Western social networks in connection with the military actions in Ukraine.

In 2017, Russian authorities required some virtual private networks companies to assist them in blocking certain content.

Many Russians continue to use virtual private networks to access websites and social networks banned by the state. This has sparked a debate among Russian lawmakers to what extent the ban on VPN services should be extended.

News agency RIA Novosti today published an inquiry by Anton Tkachev, who expresses his concerns about the plans to stop access to all such networks. He noted that, on the one hand, this ban is in line with national legislation, but on the other, “actually supports the sanctions pressure on the Russians”, since the networks in question are sometimes necessary for the continuous operation of household electrical appliances, including equipment manufactured in China.

“Based on the decision of the expert committee… filtering of specific VPN services and VPN protocols in the mobile communication network for foreign traffic that are identified as a threat may be done,” the digital ministry’s response said. development.

Template for Success: Shaping Hard Carbon Electrodes for Next-Generation Batteries

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Template for Success: Shaping Hard Carbon Electrodes for Next-Generation Batteries


Scientists use inorganic zinc-based compounds to vastly improve the capacity of sodium- and potassium-ion batteries.

Charging a car battery – illustrative photo. Image credit: JUICE via Unsplash, free license

Lithium-ion batteries (LIBs) are, by far, the most widely used type of rechargeable batteries, spanning numerous applications. These include consumer electronics, electric vehicles (e.g., Tesla cars), renewable energy systems, and spacecraft.

Although LIBs deliver the best performance in many aspects when compared to other rechargeable batteries, they have their fair share of disadvantages. Lithium is a rather scarce resource, and its price will rise quickly with its availability decreasing.

Moreover, lithium extraction and improperly discarded LIBs pose huge environmental challenges as the liquid electrolytes commonly used are toxic and flammable.

The shortcomings of LIBs have motivated researchers worldwide to look for alternative energy storage technologies. Sodium (Na)-ion batteries (NIBs) and potassium-ion batteries (KIBs) are two rapidly emerging options that are cost-efficient as well as sustainable. Both NIBs and KIBs are projected to be billion-dollar industries by the end of the decade.

Governments across the world, including that of the US, Austria, Hong Kong, Germany, and Australia, are promoting research and innovation in this field. Moreover, companies such as Faradion Limited, TIAMAT SAS, and HiNa Battery Technology Co. Ltd., are investing heavily in this technology. Both Contemporary Amperex Technology Co. Limited and Build Your Dreams are expected to introduce electric vehicle battery packs with NIBs soon.

Unfortunately, however, the capacity of the electrode materials used in NIBs and KIBs still lags behind that of LIBs. Against this backdrop, a research team led by Professor Shinichi Komaba from Tokyo University Science (TUS), Japan, has been working to develop groundbreaking high-capacity electrode materials for NIBs and KIBs.

In their latest study, published in Advanced Energy Materials on November 9, 2023, they report a new synthesis strategy for nanostructured “hard carbon” (HC) electrodes that deliver unprecedented performance. The study was co-authored by Mr. Daisuke Igarashi, Ms. Yoko Tanaka, and Junior Associate Professor Ryoichi Tatara from TUS, and Dr. Kei Kubota from the National Institute for Materials Science (NIMS), Japan.

But what is HC and why is it useful for NIBs and KIBs? Unlike other forms of carbon, such as graphene or diamond, HC is amorphous; it lacks a well-defined crystalline structure. Additionally, it is strong and resistant. In an earlier 2021 study, Prof. Komaba and his colleagues had found a way to use magnesium oxide (MgO) as a template during the synthesis of HC electrodes for NIBs, altering their final nanostructure.

The process had led to the formation of nanopores within the electrodes upon MgO removal, which, in turn, had vastly increased their capacity to store Na+ ions.

Motivated by their previous findings, the researchers explored whether compounds made from zinc (Zn) and calcium (Ca) could also be useful as nano-templates for HC electrodes. To this end, they systematically investigated different HC samples made using zinc oxide (ZnO) and calcium carbonate (CaCO3) and compared their performance with the ones synthesized using magnesium oxide (MgO).

Preliminary experiments showed that ZnO was particularly promising for the negative electrode of NIBs. Accordingly, the researchers optimized the concentration of ZnO embedded in the HC matrix during synthesis, demonstrating a reversible capacity of 464 mAh g–1 (corresponding to NaC4.8) with a high initial Coulombic efficiency of 91.7% and a low average potential of 0.18 V vs. Na+/Na.

The team achieved remarkable results by incorporating this powerful electrode material into an actual battery. “The NIB fabricated using the optimized ZnO-templated HC as the negative electrode exhibited an energy density of 312 Wh kg–1,” highlights Prof. Komaba. 

“This value is equivalent to the energy density of certain types of currently commercialized LIBs with LiFePO4 and graphite and is more than 1.6 times the energy density of the first NIBs (192 Wh kg–1), which our laboratory reported back in 2011.” Notably, the ZnO-templated HC also exhibited a significant capacity of 381 mAh g–1 when incorporated into a KIB, further showcasing its potential.

Taken together, the results of this study show that using inorganic nanoparticles as a template to control the pore structure may provide an effective guideline for the development of HC electrodes. “Our findings prove that HCs are promising candidates for negative electrodes as an alternative to graphite,” concludes Prof. Komaba.

Shaping hard carbon to obtain exceptional large-capacity electrodes for sodium-ion batteries: It is possible to incorporate nanopores in hard carbon by using zinc oxide as a template during its synthesis. These pores enable the material to store many more charge carriers, making it a promising electrode candidate for sodium-ion batteries that can reach an energy density comparable to that of LiFePO4-type lithium-ion batteries.

Shaping hard carbon to obtain exceptional large-capacity electrodes for sodium-ion batteries: It is possible to incorporate nanopores in hard carbon by using zinc oxide as a template during its synthesis. These pores enable the material to store many more charge carriers, making it a promising electrode candidate for sodium-ion batteries that can reach an energy density comparable to that of LiFePO4-type lithium-ion batteries. Image credit: Shinichi Komaba from TUS Japan

In turn, this could make NIBs viable for practical applications, such as the development of sustainable consumer electronics and electric vehicles as well as low carbon footprint energy storage systems for storing energy from solar and wind farms.

Source: Tokyo University of Science



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Digital Virology: AI’s Expert Eye Identifies Infections

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Digital Virology: AI’s Expert Eye Identifies Infections


What Guckelsberger and colleagues developed during that year is a way to automatically classify digital microscopy images of the interactions between antibodies and virus antigens in lab-grown cells. A computer essentially learns to detect if the patient has anti-coronavirus antibodies.

Beyond a diagnosis, the method also gives researchers insight into what features in cells indicate a positive result, what kind of antibody responses are present and allows them to make predictions about the likelihood of a COVID-19 antibody-positive sample from the image alone.

The same sample images classified by a computer were also shown to expert virologists, who rated them as positive or negative for coronavirus antibodies. “Our approach can match the classification level of human experts,” says Guckelsberger, “and it’s much faster. Plus, it can tell us when there are ambiguous results that should be given a closer look by an expert eye.”

The results of the project, recently published in Cell Reports Methods, also show that the method is comparable, and in some ways superior, to widely-used assays like ELISA.

“We used cells, rather than purified virus proteins, as the basis for our assay, which is closer to real physiology,” says lead author Vilja Pietiäinen of the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki.

“Because everything is completely automated, we have high throughput, but we also get the digital images that can be shown to a virologist or a pathologist, without them having to go to a microscope. The results can even be checked on a mobile device. And we can count the number of infected cells, so we have the quantitative data as well as the visuals.”

During the early days of the pandemic, the research team was able to form quickly thanks to earlier international and local collaborations on virology, imaging and drug response studies, explains Pietiäinen.

“At that point, we needed a high-throughput assay for antibody testing that would indicate if a person had a SARS-CoV-2 infection. Since then, there has been a lot of improvement on SARS-CoV-2 diagnosis, detection, and antibody response,” such as the widely familiar polymerase chain reaction (PCR) test or the antigen test (such as the nose swab) that directly measures the presence of the virus in the body.

The test developed by Pietiäinen, Guckelsberger and colleagues, by contrast, measures antibodies, which tells us how the immune system recognizes the virus and produces different types of antibodies against it.

Machine-learning-based analysis, automated workflow. Image credit: Minttu Polso/Aalto University

“When you only have a few samples, know very little about a disease or might not have access to a high-level biosafety lab, our pipeline can be really valuable,” says Guckelsberger, adding that it can be used anywhere regardless of location, sample preparation equipment or type of microscope. In fact, the pipeline is versatile to test on any germ.

“We designed the test to be used for any emerging pathogen, increasing our readiness for future pandemics,” says Pietiäinen. “Certain components should be optimized for each new virus, but the beauty of the assay is that it can be used for different purposes. It’s already being used to study zoonotic viruses like the Puumala virus.”

Other automated cell-based assays, followed by AI-guided image analysis methods, are being used in the research group to study the drug responses to SARS-CoV-2 as well as to identify drugs that can kill patient-derived cancer cells ex vivo.

Beyond publishing their work and contributing to a better understanding of the pandemic, Guckelsberger and Pietiäinen share a common insight that this project taught them.

“When big questions come up in the world, we as scientists can’t work alone in silos. Experts from different fields, different universities and countries need to come together with a shared aim—in our case, data scientists, clinicians, computer scientists, biochemists,” says Pietiäinen.

“Working in a big team, which is not something we do often in computer science, was fascinating,” echoes Guckelsberger.

“One big challenge was communicating from different perspectives of expertise, for example making sense of what is happening at both ends of the pipeline from wet lab procedures to parameters to data and images. At the same time, this was a fantastic learning experience, and one that I wish to have more of in the future.”

While they employed well-established machine learning for each component of the pipeline, Guckelsberger says making the connection between biologists and computer scientists was one of the real advances. Using technology to resolve biological questions was a big takeaway for Pietiäinen, too.

“Combining microscopy with machine learning, not just for SARS-CoV-2, but to see personalized responses to drugs or to see the cellular phenotypes of rare genetic diseases, is powerful. A picture is worth a thousand words, that is also the case here.”

Source: Aalto University



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Festivals and events not to be missed in Mechelen

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Festivals and events not to be missed in Mechelen

Mechelen, a charming city located in Belgium, is known for its rich history and lively atmosphere. Every year, the city holds various festivals and events that attract locals and tourists. Here are some of the festivals and events not to be missed in Mechelen.

One of the most popular events in Mechelen is the “Maanrock” festival. Every year, in August, the city center is transformed into a giant stage to welcome renowned local and international artists. The festival offers a varied program with live music concerts in different genres such as rock, pop, reggae and jazz. The streets are filled with food and drink stalls, creating a festive atmosphere for visitors of all ages.

Another event not to be missed is the “Mechelen Bierfestival” beer festival. This event usually takes place in the spring and allows beer lovers to discover a wide variety of craft Belgian beers. Local and international breweries present their products and offer tastings. It’s the perfect opportunity for beer lovers to discover new flavors and chat with experts in the field.

For art lovers, the “Contour” festival is an unmissable event. Held every two years, this contemporary art festival offers exhibitions, performances and film screenings in different locations across the city. Local and international artists exhibit their works, offering visitors a unique and immersive artistic experience.

Classical music lovers will not be disappointed in Mechelen. Every year, the city organizes the “Ars Musica” music festival. This event highlights high-quality classical music concerts at historic venues such as St. Rumbold’s Cathedral and the Palace of the Grand Dukes of Brabant. Renowned orchestras and virtuoso soloists perform at this festival, attracting music lovers from all over.

In addition to annual festivals, Mechelen also offers regular cultural events throughout the year. For example, the Sunday morning market is a popular meeting place for locals and visitors. The stalls offer a variety of fresh produce such as vegetables, fruits, cheeses and flowers. This is a great opportunity to taste local products and meet the producers.

The Christmas market is another event not to be missed in Mechelen. During the festive period, the town transforms into a real Christmas village with decorated chalets, food and hot drink stalls, and attractions for children. Visitors can purchase unique handcrafted gifts and enjoy the festive atmosphere.

In conclusion, Mechelen is a city that is full of interesting festivals and events throughout the year. Whether you’re a music lover, art lover, beer lover or just looking for a party atmosphere, Mechelen has something to offer everyone. Don’t miss these events and discover everything this charming city has to offer.

Originally published at Almouwatin.com